Bioanalytical Mass Spectrometry
Team Members
Former Team Members
Monzo-Fuentes Alexandre, MSc
Pechriggl Claudia, MSc
Pitterl Florian, PhD, MSc
Research Topics
The research activities mainly focus on the analysis of (bio)organic molecules in particular on the analysis of small molecules (drugs, pharmaceuticals, metabolites) as well as on the analysis of nucleic acids. The method of choice for the characterization of these species is mass spectrometry, which is in most cases hyphenated to a chromatographic method (liquid chromatography and gas chromatography). Research activities are indented to optimize the complete analytical process. We are working on the optimization of chromatographic techniques, on the improvement of the mass spectrometric detection of biomolecules, on the validation of sample preparation procedures, and the application of the established techniques in fields like forensic analysis, environmental analysis, diagnostics, therapeutic drug monitoring, metabolic profiling, genetics, as well as pharmacogenetics.
Projects
- Analysis of nucleic acids using "ion-pair reversed phase high-performance liquid chromatography electrospray ionization mass spectrometry (ICEMS)"
- Tandem mass spectrometric sequencing of nucleic acids
- Development of a tandem mass spectrometric library for the identification of small molecules
- Setup of LC/MS-based methods for the screening of drugs (e.g. urine, plasma, liquor)
- Metabolic profiling of pharmaceuticals (e.g. tetrazepam)
- Setup of LC/MS/MS-based methods for therapeutic drug monitoring
- Optimization of sample preparation techniques for the analysis of small molecules (SPE, SPME, SPDE, …)
Collaboration partners
- G. Lorbeer, Österreichisches Umweltbundesamt
- E. Csaszar, Max F. Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Biochemistry, University Vienna
- H. C. Köfeler, Core Facility for Mass Spectrometry & Chromatography, Centre for Medical Research, Medical University of Graz, Graz
- E. Weiss, Department of General Psychiatry, Innsbruck Medical University
- P. Oefner, Institute of Functional Genomics, University Regensburg
- R. Schuhmacher, M. Sulyok, Christian Doppler Laboratory for Mycotoxin Research, Department IFA-Tulln, University of Natural Resources and Applied Life Sciences, Vienna
- K. Wihsboeck, Applied Biosystems
- U. Griesser, Institute of Pharmacy, University of Innsbruck
- G. Stockhammer, M. Hutterer, Clinical Department of Neurology, Innsbruck Medical University
- T. Letzel, Biopolymer Chemistry, Technische Universität München
- D. Gjerde, PhyNexus Inc., San Jose, CA
- J.-P. Chervet, Antec, Leyden
- W. Weinmann, Institute of Forensic Medicine, Universitätsklinikum Freiburg
- M. Pircher, Iplexx IT Solutions, Innsbruck
- U. Karst, Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster
Instrumentation
- GC-MS
- LC-MS
- LC
Job offers
We are always seeking for motivated and talented individuals with background in chemistry, pharmacy, biology, or medicine to join our team. To receive information on currently open positions please contact Herbert Oberacher.
