Research
Research
Forensic Molecular Biology
In the past 20 years forensic molecular biology has faced substantial technological developments. Short Tandem Repeat (STR) loci have become the golden standard for (human) identification in crime case, ID and paternity case work. National DNA databases that consist of STR-profiles serve as powerful intelligence tool to combat crime even across boarders. Major developments have been witnessed in the field of the uniparentally inherited genomes mitochondrial and Y-chromosomal DNA. Also, the application of X-chromosomal markers has found a vital niche in forensic DNA analysis. Molecular photofitting is one of the current and future key research topics, which involves the prediction of the geographical source as well as physical traits of an individual by analysis of its DNA.
Bioanalytical Mass Spectrometry
The research activities mainly focus on the analysis of (bio)organic molecules in particular on the analysis of small molecules (drugs, pharmaceuticals, metabolites) as well as on the analysis of nucleic acids. The method of choice for the characterization of these species is mass spectrometry, which is in most cases hyphenated to a chromatographic method (liquid chromatography and gas chromatography). Research activities are indented to optimize the complete analytical process. We are working on the optimization of chromatographic techniques, on the improvement of the mass spectrometric detection of biomolecules, on the validation of sample preparation procedures, and the application of the established techniques in fields like forensic analysis, environmental analysis, diagnostics, therapeutic drug monitoring, metabolic profiling, genetics, as well as pharmacogenetics.
Between Research & Application: Special Cases
Tsunami-disaster: DNA typing of Sri Lanka victim samples and related AM matching procedures Unravelling the mystery of Nanga Parbat
Publications
Aged,80 and over Amino Acid Sequence Austria Base Sequence Begutachtung Chromatography,High Pressure Liquid DNA DNA Fingerprinting DNA Primers EMPOP Europe Germany Humans Kasuistik Metallothionein Morphologie Mutation Nucleic Acids PCR Polymorphism,Single Nucleotide Protein SINGLE SNP STR Sensitivity and Specificity Spectrometry,Mass,Electrospray Ionization Statistik Verkehrsmedizin Y-Chromosome Y-STR acid adolescence adult aged alleles amplification analysis animal autopsy biosynthesis blood case report casework cell chemistry comparative study complications control region databases etiology exercise female forensic forensic casework forensic medicine gene frequency genetics genotype genotyping haplotypes human identification immunology impact in vitro injuries instrumentation isolation & purification laboratories liquid chromatography male markers mass spectrometry metabolism methods middle age mitochondrial DNA molecular sequence data mtDNA multiplex nucleotide pathology phylogeny physiology polamerase polymerase chain reaction polymorphism population pressure reproducibility of results sequence sequence analysis short tandem repeat specimens standards surgery tandem repeat sequences therapy unklarer Tod urine
