Bioanalytical Mass Spectrometry Group and Core Facility Metabolomics

The ‘Bioanalytical Mass Spectrometry Group’ has been established as part of the Institute of Legal Medicine of the Innsbruck Medical University in 2008. Since 2011 the ‘Bioanalytical Mass Spectrometry Group’ represents the ‘Core Facility Metabolomics’ of the Innsbruck Medical University.

Mission

The mission of the Core Facility Metabolomics is to serve as an enabling resource for research and development programs at the Innsbruck Medical University. We aim to provide expertise and state-of-the-art technologies for the qualitative and quantitative analysis of small bioorganic molecules.
Common targets are drugs, pharmaceuticals, endogenous compounds, and metabolites thereof included in all kinds of biological samples (e.g. biofluids, cells, tissues).

Team Members

Assoc.Prof. Oberacher Herbert, PhD
Assoc.Prof. Oberacher Herbert, PhD
Assoc.Prof. Oberacher Herbert, PhD

Phone: +43 512 9003 70630
herbert.oberacher@i-med.ac.at


Pitterl Florian, PhD, MSc
 
Pitterl Florian, PhD, MSc

Phone: +43 512 9003 70600
florian.pitterl@i-med.ac.at


Kathrin Arnhard, Dipl.-Ing. (FH)
Kathrin Arnhard, Dipl.-Ing. (FH)
Kathrin Arnhard, Dipl.-Ing. (FH)

Phone: +43 512 9003 70630
kathrin.arnhard@i-med.ac.at


Haslacher Sandra
 
Haslacher Sandra

Phone: +43 512 9003 70630
sandra.haslacher@i-med.ac.at

    Services

    A number of immunochemistry, enzymatic, GC/MS as well as LC/MS assays are available for immediate application. A detailed list is provided here. For other targets (i.e. endogenous compounds, pharmaceutical compounds, and drugs as well as genetic markers) an assay development service is provided. Please contact Herbert Oberacher for more information.

    Research Topics

    The research activities focus on the analysis of (bio)organic molecules, including small molecules (drugs, pharmaceuticals, metabolites) and nucleic acids.
    The analytical method of choice is mass spectrometry (MS). In most cases MS is hyphenated to chromatographic methods (liquid chromatography or gas chromatography).
    Research activities are indented to optimize the complete analytical process. We are working on the optimization of chromatographic techniques, on the improvement of the mass spectrometric detection of biomolecules, on the validation of sample preparation procedures, and the application of the established techniques in fields like forensic analysis, metabolomics, environmental analysis, diagnostics, therapeutic drug monitoring, metabolic profiling, genetics, as well as pharmacogenetics.

    Bioanalysis

    Scientific Projects

    Nucleic acids analysis including genotyping

    1. Analysis of nucleic acids with “ion-pair reversed phase high-performance liquid chromatography electrospray ionization mass spectrometry (ICEMS)”
    2. Tandem mass spectrometric sequencing of nucleic acids
    3. Pharmacogenetics
    4. Electrochemical simulation of oxidation reactions involving nucleic acids

    Small molecule analysis including metabolomics

    1. Development of a tandem mass spectrometric library for the identification of small molecules - ”Wiley Registry of Tandem Mass Spectral Data, MSforID”
    2. Development and validation of analytical methods for drug monitoring and metabolomics
    3. Metabolic profiling of pharmaceuticals

    Collaborations

    Research Networks

    1. European Cooperation in Science and Technology: “Sewage biomarker analysis for community health assessment”, ESSEM COST Action ES1307, 2014-2018.
    2. Österreichische Plattform für Humanbiomonitoring

    Individual Collaborations

    1. A. Amann, Labor der Universitätsklinik für Anästhesie und Intensivmedizin, Medizinische Universität Innsbruck
    2. J.-P. Chervet, Antec, Leyden
    3. E. Csaszar, Max F. Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Biochemistry, University Vienna
    4. A. Bernkop-Schnürch, K. Leithner, Institute of Pharmacy, University of Innsbruck
    5. A. Carracedo, Institute of Forensic Science-CIBERER, University of Santiago de Compostela
    6. E. Deisenhammer, M. Defrancesco, Department of General Psychiatry, Innsbruck Medical University
    7. D. Fuchs, Division of Biological Chemistry, Biocenter, Innsbruck Medical University
    8. D.  Gjerde, PhyNexus Inc., San Jose, CA
    9. U. Griesser, Institute of Pharmacy, University of Innsbruck
    10. R. Hamberger, Lipomed GmbH
    11. J. Heis, N. Rainalter, Landespolizeidirektion Tirol, Landeskriminalamt - AB08
    12. M. Hubalek, Department of Obstetrics and Gynecology, Innsbruck Medical University
    13. J. Josephs, S. Chacko, Bristol-Myers Squibb Company, Pennington, NJ
    14. U. Karst, Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster
    15. H. C. Köfeler, Core Facility for Mass Spectrometry & Chromatography, Centre for Medical Research, Medical University of Graz
    16. T. Letzel, Analytische Forschungsgruppe am Lehrstuhl für Siedlungswasserwirtschaft, Technische Universität München
    17. J. Marksteiner, Abteilung für Psychiatrie und Psychotherapie A, LKH Hall
    18. A. Metspalu, K. Krjutškov, IMCB, University of Tartu
    19. P. Oefner, Institute of Functional Genomics, University Regensburg
    20. I. Piatkov, Diversity Health Institute, Westmead Hospital
    21. R. Schuhmacher, M. Sulyok, Christian Doppler Laboratory for Mycotoxin Research, Department IFA-Tulln, University of Natural Resources and Applied Life Sciences, Vienna
    22. B. Sperner-Unterweger, B. Holzner, A. Oberguggenberger, Department of Psychiatry and Psychotherapy, Innsbruck Medical University
    23. B. R. Steele, E. Siapi, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens
    24. G. Stockhammer, Clinical Department of Neurology, Innsbruck Medical University
    25. F. Tagliaro, R. Gottardo, Unit of Forensic Medicine, Department Public Health and Community Medicine, University of Verona
    26. W. Weinmann, Institute of Forensic Medicine, University of Bern
    27. G. Whitley, B. Berger, John Wiley & Sons, Hoboken, NJ

    Instrumentation

    Job offers

    We are always seeking for motivated and talented individuals with background in chemistry, pharmacy, biology, or medicine to join our team. To receive information on currently open positions please contact Herbert Oberacher.

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