Spontaneous remission in a secondary acute myelogenous leukaemia following invasive pulmonary aspergillosis

Tzankov,A.; Ludescher,C.; Duba,H.C.; Steinlechner,M.; Knapp,R.; Schmid,T.; Grunewald,K.; Gastl,G.; Stauder,R.
Spontaneous remission of adult acute myelogenous leukaemia (AML) represents a rare event. We report a 60-year-old female patient suffering from secondary AML M1 and severe invasive pulmonary hyalohyphomycosis highly suggestive of aspergillosis. Two months after the diagnosis of leukaemia, she achieved a spontaneous remission lasting 3 months, although neither cytostatic drugs nor corticoids were administered because of a septic condition. At the time of remission, a chronic hepatitis C virus infection and a polyclonal hypergammaglobulinaemia were present, and the patient received granulocyte colony-stimulating factor once. This report represents the first documentation of a spontaneous remission in AML following invasive pulmonary hyalohyphomycosis. Possible mechanisms of this phenomenon are discussed
Ann.Hematol. 2001 80(7):423-425
Tags: adult; Aspergillosis; Austria; Bone Marrow; case report; complications; diagnosis; female; Germany; human; Leukemia,Myelocytic,Acute; Lung; Lung Diseases,Fungal; microbiology; middle age; pathology; physiopathology; radiography; Remission,Spontaneous; Tomography,X-Ray Computed
PubMed: 11529469
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