Research

Research

Forensic Molecular Biology

In the past 20 years forensic molecular biology has faced substantial technological developments. Short Tandem Repeat (STR) loci have become the golden standard for (human) identification in crime case, ID and paternity case work. National DNA databases that consist of STR-profiles serve as powerful intelligence tool to combat crime even across boarders. Major developments have been witnessed in the field of the uniparentally inherited genomes mitochondrial and Y-chromosomal DNA. Also, the application of X-chromosomal markers has found a vital niche in forensic DNA analysis. Molecular photofitting is one of the current and future key research topics, which involves the prediction of the geographical source as well as physical traits of an individual by analysis of its DNA.

Bioanalytical Mass Spectrometry

The research activities mainly focus on the analysis of (bio)organic molecules in particular on the analysis of small molecules (drugs, pharmaceuticals, metabolites) as well as on the analysis of nucleic acids. The method of choice for the characterization of these species is mass spectrometry, which is in most cases hyphenated to a chromatographic method (liquid chromatography and gas chromatography). Research activities are indented to optimize the complete analytical process. We are working on the optimization of chromatographic techniques, on the improvement of the mass spectrometric detection of biomolecules, on the validation of sample preparation procedures, and the application of the established techniques in fields like forensic analysis, environmental analysis, diagnostics, therapeutic drug monitoring, metabolic profiling, genetics, as well as pharmacogenetics.

Between Research & Application: Special Cases

Tsunami-disaster: DNA typing of Sri Lanka victim samples and related AM matching procedures Unravelling the mystery of Nanga Parbat

Publications

Publications Index

Aged,80 and over Austria Begutachtung DISCRIMINATION DNA DNA Fingerprinting EMPOP Europe FORENSIC-GENETICS Forensic Genetics GENE Germany Humans Kasuistik Morphologie Mutation PCR PERFORMANCE Probability Protein SEARCH SENSITIVITY SINGLE SNP STR TANDEM REPEAT VALIDATION Y-Chromosome Y-STR acid adult aged alleles amplification analysis animal autopsy blood case report casework cell chemistry comparative study control region databases electrospray ionization etiology exercise female forensic forensic casework forensic medicine forensic science gene frequency genetics genotype genotyping haplotypes human identification immunology impact in vitro injuries instrumentation isolation & purification laboratories liquid chromatography loci male markers mass spectrometry metabolism methods middle age mitochondrial DNA molecular sequence data mtDNA multiplex multiplexes nucleotide pathology phylogeny physiology polymerase chain reaction polymorphism population reproducibility of results sequence sequence analysis short tandem repeat small specimens standards surgery system tandem repeat sequences therapy unklarer Tod urine
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